Reduces inflammation and fever, amapachana, part of dashamula other traditional uses. Pdf identification of acteoside as the active antioxidant principle of. Antiatherosclerotic activity of root bark of premna. Harvesting should be done thereafter towards the end of rainy season, that is, septemberoctober. Glycosides isolated from the aerial parts of premna. The premna genus can be used traditionally in treating various ailments like rheumatism, asthma, dropsy, cough, fever, boils and scrofulous diseases. Preliminary pharmacological activity of the methanolic. Ecological biodiversity, phytochemistry, premna integrifolia, traditional uses.
Chemical composition and antioxidant activity of essential. These extracts were dried using a rotatory evaporator followed by. Pdf evaluation of in vitro antioxidant activity of stem. Sattar a a department of applied chemistry and chemical technology, islamic university, kushtia 7003, bangladesh b department of biotechnology and genetic. Sorry, we are unable to provide the full text but you may find it at the following locations. Essential oils have emerged as viable alternatives to synthetic insecticides for control of mosquitoborne pathogens. The plant is known to possess hypoglycaemic, antiinflammatory, antiarthritic and broadspectrum antimicrobial activities due to the presence of several diterpenoids and spermine alkaloids in its decoction.
Original article in vitro antibacterial properties of essential oil and organic extracts of premna integrifolia linn atiqur rahman a, zakia sultana shanta a, m. The different parts of the plant like leaves, stem, stem barks, root, root barks and wood have been used for extraction purpose. It is one of the important constituents among ten herb formulations called dashmula, a favorite decoction of ten plants. Premna is a scandent, erect shrub or small tree, more or less thorny on the trunk and large. Premna integrifolia is one the most widely used plant in the ayurvedic system of medicine. The genus premna verbenaceae is widely distributed in tropical and subtropical regions of africa, asia, australia and the pacific islands kadareit, 2004. Apr 05, 2021 phytochem ical study on t he plant premna integrifolia l. Premna serratifolia is used by the traditional practitioners as cardiotonic, antibiotic, anticoagulant, stomachic, carminative, hepatoprotective, antitumor etc. Review of medicinal plants for antiobesity activity. Antibiotic substance from the root bark of premna integrifolia.
Exploration of antibacterial and antiinflammatory activities. Premna serratifolia, lignan, triterpenoids, antimelanin deposition activity, myanmar. Premna integrifolia is large shrub or a small tree distributed on the western seacoast. Verbenaceae synonym of premna integrifolia, otherwise known as agnimantha in ayurvedic system of medicine, is a smallsized tree or a large shrub, up to 9m in height with a comparatively short trunk and numerous branches. In vitro antibacterial properties of essential oil and. Phytochemical study on the plant premna integrifolia l. Isolation of scutellarein from pygmaeopremna herbacea.
Plant species parts used chemical constituents activity references premna integrifolia leaves phytol. Rashid a, tanzima parvin a, shajia afrin b, mst khodeza khatun a, m. Intercultural operations include manual weeding and hoein. On the scientific basis of traditional uses, the ethanolic extract of leaves of premna integrifolia linn. Verbenaceae synonym of premna serratifolia has tremendous medicinal value. The leaf essential oils of eight species of premna lamiaceae growing in central vietnam have been obtained by hydrodistillation and analyzed by gas chromatographymass spectrometry. In the philippines, particularly in cebu island, it is usually found in. Stem branches were cut into small pieces, dried under shade for about 15 days, milled, shifted through sieve 2530 no. Effect of aqueous enriched fraction of premna integrifolia root against cafeteria diet induced obesity. The oil was dried over anhydrous na 2so 4 and preserved in a sealed vial at 4 c for further analysis. Other compilations list them as synonymous species. Ayurvedic herbs letters a agnimantha premna integrifolia agnimantha or arani or arni.
Here we have provided clinical definition, causes or contributing factors and how you can think of naturally treating constipation with ayurveda. Quisumbings compilation lists premna integrifolia blanco as a separate specie from premna serratifolia l. Premna integrifolia, is a small tree or shrub that occur in india, srilanka and the andaman. Iridoid compound 10otranspcoumaroylcatalpol extends. Aging, the major cause of several ailments has led to intense exploration of potential drugs that delay aging and its associated effects.
Preparation of organic extracts the airdried leaves p. Simultaneous quantification of diterpenoids in premna. A new tetrahydrofuran lignan from premna serratifolia wood. Free radical scavenging potential of hydroalcoholic root extract of premna integrifolia. Ambasta sp, ramachandran k, kashyapa k and chand r. Acute and subacute toxicity of the extract was studied in mice of both sexes to get an idea about ld 50 value and assessed its safety profile before its. Request pdf diterpenoids from premna integrifolia premna integrifolia is an important constituent of famous herbal formulation dashmula of indian ayurvedic system of medicines. The structure of the new compound was determined using various.
Humulene, spathulenol,1octen3l,eugenol, phenyl ethyl alcohol antibacterial. Verbanacea are known under the common name arniagnimantha. Part xiii phenolic diterpenoids from root bark of premna integrifolia. Premna integrifolia is known to constitute numerous phytochemicals that have rightfully deemed it an indispensable component of the dashamoola and continues to be researched on in the field of modern medicine. Study on the chemical constituents of premna integrifolia l. Council of scientific and industrial research, new delhi, p. Rapid in vitro propagation of premna serratifolia, a medicinally. Temperature had a significant influence on the dpph free radical scavenging. Constipation or the hard to pass bowel movement is one of the commonest health problems all over the world. Eaepi leaves in cyclophosphamide cpinduced hepatic injury in mice. Downloaded free from on thursday, april 16, 2020, ip. Preliminary pharmacological studies were performed on the methanolic extract of premna integrifolia mepi bark to investigate neuropharmacological, analgesic, and antiinflammatory activities.
Roots of both the plants are important rasayana drugs and are considered to be useful in the treatment of variety of ailments. Evaluation of immunomodulatory activity of clerodendrum. Phytochemical profiling and cytotoxic evaluation of premna. Premna integrifolia international journal of green pharmacy. Phytochem ical study on t he plant premna integrifolia l. Pharmacological potentials of premna integrifolia l. Their chemical structures were elucidated by means of esims, 1 hnmr, cnmr, hsqc, hmbc spectra and in comparison with the previous literature. In vietnam, it is cultivated as an ornamental and shade tree. Lam family lamiaceae not a type of premna serratifolia l. Diterpenoids from premna integrifolia sciencedirect. However, oxygencentered free radicals and other reactive oxygen. The plant should remain in the field at least for a period of three years.
Preparation of premna integrifolia extracts the young roots and leaves of premna integrifolia were sun dried for 15 days, powdered and successively extracted with soxhlet apparatus with petroleum ether, ethyl acetate, methanol and water in the increasing polarity index. Toxicity profiling and antioxidant activity of ethyl. In whic h, a new acylate d iridoid gly coside, 6 o 3. We mined the information on traditional indian medicines and identified an iridoid, 10otransp coumaroylcatalpol occ, a major ingredient of premna integrifolia linn. Influence of light intensity and temperature on antioxidant. Pdf on apr 21, 2019, atul kabra published 7 ak jbcc 1 1 find, read and cite all the research you need on. Department of pharmacognosy, mahatma gandhi vidyamandirs pharmacy college, panchavati, nashik, maharashtra, india. Quisumbings compilation lists premna integrifolia blanco as a separate specie from premna serratifolia blanco. Nov 01, 2018 the present study was designed to evaluate the ameliorative effect of ethyl acetate extract of premna integrifolia l. Ethnomedicinal uses, phytochemistry and pharmacological aspects. The genus premna lamiaceae, distributed throughout tropical and.
Identification of acteoside as the active antioxidant. Antiarthritic activity of premna serratifolia linn. The various premna species are well known for their medicinal properties and have been used in indian traditional system of medicine especially for diarrhea, stomach and hepatic disorders. Sep 20, 2010 premna integrifolia is an important constituent of famous herbal formulation dashmula of indian ayurvedic system of medicines. The genus premna verbenaceae, consists of about 200 species that are native mainly to the tropical and subtropical asia, africa, australia and the pacific islands. Antimicrobial activity of some vietnamese medicinal plants. Lamiaceae is widely used in herbal formulation dashmoolarishta which is useful in postnatal care. Lignans with melanogenesis effects from premna serratifolia wood. Pdf toxicity profiling and antioxidant activity of ethyl. Verbenaceae is a medicinal plant which is traditionally used against a number of diseases including inflammatory condition.
Ieee sem, volume 7, issue 8, august 2019 issn 2320 9151. Sesquiterpene hydrocarbons dominated most of the premna essential oils, with the notable. Mali py, bigoniya p, panchal ss, muchhandi is 20 antiobesity activity of chloroformmethanol extract of premna integrifolia in mice fed with cafeteria diet. There is no report on acute and subacute toxicity study of p. The pdf is free to circulate or add to other websites. Premna integrifolia has great importance in traditional medicine worldwide due to its use for the treatment of rheumatism, asthma, dropsy, beriberi and vaginal irritation. The leaf explants excised from 8 years old premna serratifolia l. On the other hand, other premna species are particularly rich in low molecular weight alcohols such as 1octen3ol in premna barbata 37.
Pharmacognostical tool are helpful in authentication of root bark of p. To our best knowledge, this is the first report of 1 and 3 from p. A significant number of modern pharmaceutical drugs are thus based on or derived from medicinal plants. Integrifolia is comparatively smaller known as shrub i. Chemical composition and antioxidant activity of essential oil and. A sensitive, selective and robust densitometric high. In contrast, the essential oil of premna microphylla was dominated by the sesquiterpenoid derivative blumenol c 49. Part xnew isoprenoids from the root barks of premna 403 407. Validation and development of hptlc method for simultaneous. Ethyl acetate extract obtained from the leaves was evaluated for phenolic content and its antioxidant activity.
Toxicity profiling and antioxidant activity of ethyl acetate. The study showed that the methanolic extract of plant has free radical. Clerodendrin a, a chemical marker was isolated from the root of clerodendrum phlomidis verbanaceae. Agnimantha premna integrifolia agnimantha or arani or arni ayurveda characteristic and uses effect on doshas pacifies vata and kapha taste bitter, pungent, sweet, astringent energetics heating main traditional action. Additional sources and suggested readings 1 antibiotic substance from the root bark of premna integrifolia k k kurup and p a kurup naturwissenschaften, january 1964, volume 51, no 20 doi 10. It is large shrub or small tree up to 10 m tall, bole up to 30 cm in diameter, muchbranched and sometimes spiny, bark fissuredflaky, brownishgrey and branches are spinous usually. Pdf diterpenoids from premna integrifolia neerja tiwari. Kamiya t, sameshimakamiya m, nagamine r, tsubata m, ikeguchi m, et al. Ethyl acetate extract obtained from the leaves was evaluated for. Premna serratifolia has been used to treat inflammatory disorders because it. Further, hptlc method was developed to quantify isolated clerodendrinain c.
The current study was focused to evaluate the cytotoxic potential of aqueous extract of root of p. Pdf pharmacological potentials of premna integrifolia l. We here report first time, the presence of clerodendrinain another verbanaceae drug, premna integrifolia. Dried powder packed in air tight container and stored to cool, dry condition. Edema, diseases of the urinary tract, diabetes, dyspepsia, flatulent colic. Premna is a scandent, erect shrub or small tree, more or less thorny on the trunk and. Pdf study on the chemical constituents of premna integrifolia l. Premna integrifolia ameliorates cyclophosphamideinduced. It mostly grow in moist sandy soil and scrub jungles along seacoasts and mangrove forests. You can also use them for free as per creative commons license attached with each image. Phytochemical investigation of the chcl 3 extract of premna serratifolia syn.
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